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On the irrationality of rational design of an HIV vaccine in light of protein intrinsic disorderстатья
- Автор: Uversky V.N.
- Журнал: Archives of Virology
- Том: 166
- Номер: 5
- Год издания: 2021
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 1283
- Последняя страница: 1296
- Аннотация: The lack of progress in finding an efficient vaccine for a human immunodeficiency virus (HIV) is daunting. In fact, this search has spanned nearly four decades without much success. There are several objective reasons for such a failure, which include the highly glycosylated nature of HIV-1, the presence of neotopes, and high mutation rates. This article argues that the presence of highly flexible and intrinsically disordered regions in both human anti-HIV-1 antibodies and the major HIV-1immunogen, its surface glycoprotein gp120, represent one of the major causes for the lack of success in utilization of structure-based reverse vaccinology.
- Добавил в систему: Уверский Владимир Николаевич