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Pesticides directly accelerate the rate of $\upalpha$-synuclein fibril formation: a possible factor in Parkinson\textquotesingles diseaseстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Uversky Vladimir N., Li Jie, Fink Anthony L.
- Журнал: FEBS Letters
- Том: 500
- Номер: 3
- Год издания: 2001
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 105
- Последняя страница: 108
- DOI: 10.1016/s0014-5793(01)02597-2
- Аннотация: Parkinson's disease involves intracellular deposits of alpha-synuclein in the form of Lewy bodies and Lewy neurites. The etiology of the disease is unknown, however, several epidemiological studies have implicated environmental factors, especially pesticides. Here we show that several pesticides, including rotenone, dieldrin and paraquat, induce a conformational change in alpha-synuclein and significantly accelerate the rate of formation of alpha-synuclein fibrils in vitro. We propose that the relatively hydrophobic pesticides preferentially bind to a partially folded intermediate conformation of alpha-synuclein, accounting for the observed conformational changes, and leading to association and subsequent fibrillation. These observations suggest one possible underlying molecular basis for Parkinson's disease.
- Добавил в систему: Уверский Владимир Николаевич