Ferrocenylalkyl Azoles. Bioactivity, Synthesis, Structure

Snegur, L.V.; Nekrasov, Y.S.; Sergeeva, N.S.; Zhilina, Z.V.; Gumenyuk, V.V.; Starikova, Z.A.; Simenel, A.A.; Morozova, N.B.; Sviridova, I.K.; Babin, V.N.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 марта 2017 г.

Авторы: Snegur L.V., Nekrasov Yu S., Sergeeva N.S., Zhilina Zh V., Gumenyuk V.V., Starikova Z.A., Simenel A.A., Morozova N.B., Sviridova I.K., Babin V.N.
Журнал: Applied Organometallic Chemistry
Том: 22
Год издания: 2008
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Первая страница: 139
Последняя страница: 147
Аннотация: The toxicity of ferrocenylethyl benzotriazole and other ferrocene compounds including ferrocenylmethyl benzimidazoles, ferricenium salts and ferrocenylmethyl adenine, was studied. All ferrocene complexes under investigation showed low or medium toxicities. On the basis of an earlier model of chemical carcinogenesis, the antitumor activity of ferrocenylalkyl azoles and ferricenium salts was studied in vivo in the so-called subcapsular test on human tumors. This effectiveness was compared with that of cisplatin. A series of ferrocenylalkyl azoles were synthesized by interacting azoles either with α-hydroxyalkyl ferrocenes FcC(OH)R1R2 in organic solvent in the presence of aqueous HBF4 in quantitative yields or with trimethyl(aminomethyl)ferrocene iodide in an aqueous-basic medium in good yields. The X-ray determinations of molecular and crystal structures of α-(1-benzotriazolyl)ethylferrocene and α-(1-naphthatriazolyl)ethylferrocene were performed.
Добавил в систему: Сименел Александр Александрович

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Ferrocenylalkyl Azoles. Bioactivity, Synthesis, Structureстатья

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