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Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL’2(NO)2][FeL’L”(NO)2] with L’-thiobenzamide and L”-thiosulfateстатья
- Авторы: Sanina N.A., Starostina A.A., Utenyshev A.N., Dorovatovskii P.V., Emel’yanova N.S., Krapivin V.B., Luzhkov V.B., Mumyatova V.A., Balakina A.A., Terentiev A.A., Aldoshin S.M.
- Журнал: Molecules
- Том: 27
- Номер: 20
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 6886
- DOI: 10.3390/molecules27206886
- Аннотация: In this work a new donor of nitric oxide (NO) with antibacterial properties, namely nitrosyliron complex of [Fe(C6H5C-SNH2)2(NO)2][Fe(C6H5C-SNH2)(S2O3)(NO)2] composition (complexI), has been synthesized and studied. Complex I was produced by the reduction of the aqueoussolution of [Fe2(S2O3)2(NO)2]2 dianion by the thiosulfate, with the further treatment of the mixtureby the acidified alcohol solution of thiobenzamide. Based on the structural study of I (X-ray analysis,quantum chemical calculations by NBO and QTAIM methods in the frame of DFT), the data wereobtained on the presence of the NO . . . NO interactions, which stabilize the DNIC dimer in the solidphase. The conformation properties, electronic structure and free energies of complex I hydrationwere studied using B3LYP functional and the set of 6–31 + G(d,p) basis functions. The effect of anaquatic surrounding was taken into account in the frame of a polarized continuous model (PCM).The NO-donating activity of complex I was studied by the amperometry method using an “amiNO-700” sensor electrode of the “inNO Nitric Oxide Measuring System”. The antibacterial activity ofI was studied on gram-negative (Escherichia coli) and gram-positive (Micrococcus luteus) bacteria.Cytotoxicity was studied using Vero cells. Complex I was found to exhibit antibacterial activitycomparable to that of antibiotics, and moderate toxicity to Vero cells.
- Добавил в систему: Алдошин Сергей Михайлович