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Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activityстатья
- Авторы: Negrya Sergey D., Jasko Maxim V., Makarov Dmitriy A., Karpenko Inna L., Solyev Pavel N., Chekhov Vladimir O., Efremenkova Olga V., Vasilieva Byasilya F., Efimenko Tatiana A., Kochetkov Sergey N., Alexandrova Liudmila A.
- Журнал: Mendeleev Communications
- Том: 32
- Номер: 4
- Год издания: 2022
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 433
- Последняя страница: 435
- DOI: 10.1016/j.mencom.2022.07.002
- Аннотация: In order to develop a new generation of antibacterial nucleosides, a representative set of novel 3'- and 5'-tri- or tetraethylene glycol prodrug forms of 5-alkyloxymethyl-2'- deoxyuridines was synthesized. These compounds were at least two orders of magnitude more soluble than the parent nucleosides, possessed significant inhibitory activity against a set of bacteria including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis, and showed low cytotoxicity. The obtained data indicate that glycol carbonates are convenient and prospective for usage in prodrugs of nucleoside derivatives with antibacterial activity.
- Добавил в систему: Сольев Павел Николаевич