Adjuvant vemurafenib in resected, BRAF V600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

Maio, M.; Lewis, K.; Demidov, L.; Mandalà, M.; Bondarenko, I.; Ascierto, P.A.; Herbert, C.; Mackiewicz, A.; Rutkowski, P.; Guminski, A.; Goodman, G.R.; Simmons, B.; Ye, C.; Yan, Y.; Schadendorf, D.; Cinat, G.; Fein, L.E.; Brown, M.; Guminski, A.; Haydon, A.; Khattak, A.; McNeil, C.; Parente, P.; Power, J.; Roberts-Thomson, R.; Sandhu, S.; Underhill, C.; Varma, S.; Berger, T.; Awada, A.; Blockx, N.; Buyse, V.; Mebis, J.; Franke, F.A.; de Azevedo, S.J.; Lazaretti, N.S.; Jamal, R.; Mihalcioiu, C.; Petrella, T.; Savage, K.; Song, X.; Wong, R.; Dabelic, N.; Plestina, S.; Vojnovic, Z.; Arenberger, P.; Kocak, I.; Krajsova, I.; Kubala, E.; Melichar, B.; Vantuchova, Y.; Putnik, K.; Dreno, B.; Dutriaux, C.; Grob, J.; Joly, P.; Lacour, J.; Meyer, N.; Mortier, L.; Thomas, L.; Fluck, M.; Gambichler, T.; Hassel, J.; Hauschild, A.; Schadendorf, D.; Donnellan, P.; McCaffrey, J.; Power, D.; Ariad, S.; Bar-Sela, G.; Hendler, D.; Ron, I.; Schachter, J.; Ascierto, P.; Berruti, A.; Bianchi, L.; Sileni, V.C.; Cognetti, F.; Danielli, R.; Giacomo Anna, M.D.; Gianni, L.; Goldhirsch, A.; Guida, M.; Maio, M.; Mandalà, M.; Marchetti, P.; Queirolo, P.; Santoro, A.; Kapiteijn, E.; Mackiewicz, A.; Rutkowski, P.; Ferreira, P.; Demidov, L.; Gafton, G.; Makarova, Y.; Andric, Z.; Babovic, N.; Jovanovic, D.; Sekulovic, L.K.; Cohen, G.; Dreosti, L.; Vorobiof, D.; Garcia Maria, T.C.; Beveridge, R.D.; Tarruella, M.M.; Rodas, I.M.; Rodriguez, J.P.; Dominguez, A.R.; Maroti, M.; Papworth, K.; Michielin, O.; Bondarenko, I.; Brown, E.; Corrie, P.; Harries, M.; Herbert, C.; Kumar, S.; Martin-Clavijo, A.; Middleton, M.; Patel, P.; Talbot, T.; Agarwala, S.; Chapman, P.; Conry, R.; Doolittle, G.; Gangadhar, T.; Hallmeyer, S.; Hamid, O.; Hernandez-Aya, L.; Johnson, D.; Kass, F.; Kolevska, T.; Lewis, K.; Lunin, S.; Salama, A.; Sikic, B.; Somer, B.; Spigel, D.; Whitman, E.

Авторы: Maio Michele, Lewis Karl, Demidov Lev, Mandalà Mario, Bondarenko Igor, Ascierto Paolo A., Herbert Christopher, Mackiewicz Andrzej, Rutkowski Piotr, Guminski Alexander, Goodman Grant R., Simmons Brian, Ye Chenglin, Yan Yibing, Schadendorf Dirk, Cinat Gabriela, Fein Luis Enrique, Brown Michael, Guminski Alexander, Haydon Andrew, Khattak Adnan, McNeil Catriona, Parente Phillip, Power Jeremy, Roberts-Thomson Rachel, Sandhu Shahneen, Underhill Craig, Varma Suresh, Berger Thomas, Awada Ahmad, Blockx Nathalie, Buyse Veronique, Mebis Jeroen, Franke Fábio André, de Azevedo Sérgio Jobim, Lazaretti Nicolas Silva, Jamal Rahima, Mihalcioiu Catalin, Petrella Teresa, Savage Kerry, Song Xinni, Wong Ralph, Dabelic Nina, Plestina Stjepko, Vojnovic Zeljko, Arenberger Petr, Kocak Ivo, Krajsova Ivana, Kubala Eugen, Melichar Bohuslav, Vantuchova Yvetta, Putnik Kadri, Dreno Brigitte, Dutriaux Caroline, Grob Jean-Jacques, Joly Pascal, Lacour Jean-Philippe, Meyer Nicolas, Mortier Laurent, Thomas Luc, Fluck Michael, Gambichler Thilo, Hassel Jessica, Hauschild Axel, Schadendorf Dirk, Donnellan Paul, McCaffrey John, Power Derek, Ariad Samuel, Bar-Sela Gil, Hendler Daniel, Ron Ilan, Schachter Jacob, Ascierto Paolo, Berruti Alfredo, Bianchi Luca, Sileni Vanna Chiarion, Cognetti Francesco, Danielli Riccardo, Giacomo Anna Maria Di, Gianni Luca, Goldhirsch Aron, Guida Michele, Maio Michele, Mandalà Mario, Marchetti Paolo, Queirolo Paola, Santoro Armando, Kapiteijn Ellen, Mackiewicz Andrzej, Rutkowski Piotr, Ferreira Paula, Demidov Lev, Gafton Georgy, Makarova Yulia, Andric Zoran, Babovic Nada, Jovanovic Darjana, Sekulovic Lidija Kandolf, Cohen Graham, Dreosti Lydia, Vorobiof Daniel, Garcia Maria Teresa Curiel, Beveridge Roberto Diaz, Tarruella Margarita Majem, Rodas Ivan Marquez, Rodriguez Jose-M Puliats, Dominguez Antonio Rueda, Maroti Marianne, Papworth Karin, Michielin Olivier, Bondarenko Igor, Brown Ewan, Corrie Pippa, Harries Mark, Herbert Christopher, Kumar Satish, Martin-Clavijo Agustin, Middleton Mark, Patel Poulam, Talbot Toby, Agarwala Sanjiv, Chapman Paul, Conry Robert, Doolittle Gary, Gangadhar Tara, Hallmeyer Sigrun, Hamid Omid, Hernandez-Aya Leonel, Johnson Douglas, Kass Frederic, Kolevska Tatjana, Lewis Karl, Lunin Scott, Salama April, Sikic Branimir, Somer Bradley, Spigel David, Whitman Eric
Журнал: Lancet Oncology
Том: 19
Номер: 4
Год издания: 2018
Издательство: The Lancet Publishing Group
Местоположение издательства: United Kingdom
Первая страница: 510
Последняя страница: 520
DOI: 10.1016/s1470-2045(18)30106-2
Аннотация: Systemic adjuvant treatment might mitigate the high risk of disease recurrence in patients with resected stage IIC-III melanoma. The BRIM8 study evaluated adjuvant vemurafenib monotherapy in patients with resected, BRAFV600 mutation-positive melanoma.
Добавил в систему: Демидов Лев Вадимович

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Adjuvant vemurafenib in resected, BRAF V600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trialстатья