Аннотация:Linear-hyperbranched co(polylactides) containing hyperbranched polyglycerol block were synthesized and characterized. An estimate of critical micelle concentration as well as aggregative stability and droplet sizes in the emulsion stabilized by the obtained polymers was made. It was shown that an architecture of linear-branched co(polylactides) defines its surface-active properties and characteristics of dispersion systems obtained from it. With an increase in polyglycerol blocks content in copolymers critical micelle concentration and aggregative stability of emulsions stabilized increase. Polylactide microparticles were obtained by organic solvent evaporation technique using acetylsalicylic acid as a drug model. Some properties of micropaticle, such as size, incorporation efficiency and in vitro release of immobilized substance, were examined. It was noticed that branching architecture of co(polylactides) has a significant influence on properties of microparticles. On the one hand, a presence of large PG blocks in linear-branched macromolecules results in the formation of colloidal systems with higher aggregative stability of emulsions and smaller particle size; on the other hand, microparticles formed from such copolymers have lower incorporation efficiency towards water-soluble low molecular compounds and nonlinear release profile for these substances with a segment of accelerated primary release.
