|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Drug toxicity assessment: cell proliferation versus cell deathстатья Электронная публикация
- Авторы: Sazonova Elena V., Chesnokov Mikhail S., Zhivotovsky Boris, Kopeina Gelina S.
- Журнал: Cell Death Discovery
- Том: 8
- Год издания: 2022
- Номер статьи: 417
- DOI: 10.1038/s41420-022-01207-x
- Аннотация: Analysis of the toxicity of chemotherapeutic drugs is one of the main tasks of clinical pharmacology. Decreased viability of tumor cells may reflect two important physiological processes, namely the arrest of proliferation associated with disturbances in cellular metabolism or actual cell death. Elucidation of the exact processes mediating a reduction in the number of cells is fundamentally important to establish the mechanisms of drug action. Only the use of a combination of cell biological and biochemical approaches makes it possible to understand these mechanisms. Here, using various lines of tumor cells and a set of methodological approaches, we carried out a detailed comparative analysis and demonstrated the possible ways to overcome the uncertainties in establishing the mechanisms of cell response to the action of chemotherapeutic drugs and their toxicity.
- Добавил в систему: Чесноков Михаил Сергеевич