Rodent models of audiogenic epilepsy: genetic aspects, ad-vantages, current problems and perspectives

Авторы: Garbuz D.G., Davletshin A.I., Litvinova S.A., Fedotova I.B., Surina N.M., Poletaeva I.I.
Журнал: BIOMEDICINES
Том: 10
Номер: 10/11
Год издания: 2022
Первая страница: 2934
DOI: 10.3390/biomedicines10112934
Аннотация: Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, search for new genes and regulatory pathways involved in the development of epilepsy, as well as for screening of new antiepileptic drugs. Today, many meth-ods of modeling epilepsy in animals are used: electroconvulsive, pharmacological in intact ani-mals, and genetic, with the predisposition to spontaneous or refractory epileptic seizures. Due to the simplicity of manipulation and universality, genetic models of audiogenic epilepsy in rodents stand out among this diversity. We tried to combine data on the genetics of audiogenic epilepsy in rodents, the relevance of various models of audiogenic epilepsy to certain epileptic syndromes in humans, and the advantages of using of rodent strains predisposed to audiogenic epilepsy in cur-rent epileptology.
Добавил в систему: Федотова Ирина Борисовна

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