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Protectors of the Mitochondrial Permeability Transition Pore Activated by Iron and Doxorubicinстатья
- Авторы: Fedotcheva Tatiana A., Fedotcheva Nadezhda I.
- Журнал: Current Cancer Drug Targets
- Том: 21
- Номер: 6
- Год издания: 2021
- Издательство: Bentham Science Publishers
- Местоположение издательства: Netherlands
- Первая страница: 514
- Последняя страница: 525
- DOI: 10.2174/1568009621999210120192558
- Аннотация: The study is aimed at examining of action of iron, DOX, and their complex on theMitochondrial Permeability Transition Pore (MPTP) opening and detecting of possible protectorsof MPTP in the conditions close to mitochondria-dependent ferroptosis.MPTP and the respiratory complex II are identified as the main targets of the iron-dependent action of DOX on the isolated mitochondria. All MPTP protectors tested abolished or weakened the effect of iron and a complex of iron with DOX on Ca2+ -induced MPTP opening, acting in different stages of MPTP activation.
- Добавил в систему: Федотчева Надежда Ивановна