Аннотация:Combinations of anticancer chemotherapeutics with glucocorticoids (GCs) are usually used to broaden the therapeutic range of main cytostatic agents and to diminish the side effects of chemotherapy. However, long-term GC administration leads to tumor resistance and the promotion of metastasis. GC effects are mediated by the glucocorticoid receptor, which regulates gene expression via DNA-dependent transactivation associated with GC side effects and therapeutically important transrepression. We aimed to determine the molecular markers associated with the GC-stimulated motility and migration of breast cancer cells. We showed that GCs stimulate the invasion and metastasis of breast cancer cells after 120 h of treatment and determined markers of GC-associated adhesion loss.
Supplementary Materials
The following are available online at https://www.mdpi.com/article/10.3390/IECBM2022-13379/s1.
Funding
Work was partially supported by RSCF (17-75-20124) and RFBR (16-04-01410, 15-04-04006).