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α-Diimine Cisplatin Derivatives: Synthesis, Structure, Cyclic Voltammetry and Cytotoxicityстатья
- Авторы: Yambulatov Dmitriy S., Lutsenko Irina A., Nikolaevskii Stanislav A., Petrov Pavel A., Smolyaninov Ivan V., Malyants Irina K., Shender Victoria O., Kiskin Mikhail A., Sidorov Alexey A., Berberova Nadezhda T., Eremenko Igor L.
- Журнал: Molecules
- Том: 27
- Номер: 23
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 8565
- DOI: 10.3390/molecules27238565
- Аннотация: Abstract: Three new Pt(II) complexes [(dpp-DAD)PtCl2] (I), [(Mes-DAD(Me)2)PtCl2] (II) and [(dpp-DAD(Me)2)PtCl2] (III) were synthesized by the direct reaction of [(CH3CN)2PtCl2] and correspondingredox-active 1,4-diaza-1,3-butadienes (DAD). The compounds were isolated in a single crystal formand their molecular structures were determined by X-ray diffraction. The purity of the complexesand their stability in solution was confirmed by NMR analysis. The Pt(II) ions in all compoundsare in a square planar environment. The electrochemical reduction of complexes I–III proceeds intwo successive cathodic stages. The first quasi-reversible reduction leads to the relatively stablemonoanionic complexes; the second cathodic stage is irreversible. The coordination of 1,4-diaza-1,3-butadienes ligands with PtCl2 increases the reduction potential and the electron acceptor ability ofthe DAD ligands. The synthesized compounds were tested in relation to an adenocarcinoma of theovary (SKOV3). (PDF) α-Diimine Cisplatin Derivatives: Synthesis, Structure, Cyclic Voltammetry and Cytotoxicity. Available from: https://www.researchgate.net/publication/366021747_a-Diimine_Cisplatin_Derivatives_Synthesis_Structure_Cyclic_Voltammetry_and_Cytotoxicity
- Добавил в систему: Мальянц Ирина Кареновна