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Modifiers of Membrane Dipole Potentials as Tools for Investigating Ion Channel Formation and Functioningстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 21 августа 2017 г.
- Авторы: Ostroumova Olga S., Efimova Svetlana S., Malev Valery V.
- Сборник: International Review of Cell and Molecular Biology
- Том: 315
- Глава в коллективной монографии
- Год издания: 2015
- Место издания: Elsevier BV
- Первая страница: 245
- Последняя страница: 297
- DOI: 10.1016/bs.ircmb.2014.12.001
- Аннотация: Electrostatic fields generated on and within biological membranes are recognized to play a fundamental role in key processes in cell functions. The role of the membrane dipole potential is of particular interest because of its powerful impact on membrane permeability and lipid-protein interactions, including protein insertion, oligomerization, and function. The membrane dipole potential is defined by the orientation of the electric dipoles of the lipid headgroups, fatty acid carbonyl groups, and membrane-adsorbed water. As a result, the membrane interior is several hundred millivolts more positive then the external aqueous phase. This potential decrease depends on the lipid, and especially sterol, composition of the membrane. The adsorption of certain electroneutral molecules known as dipole modifiers may also lead to significant changes in the magnitude of the potential decrease. These agents are widely used to study the effects of the dipole potential on membrane transport. This review represents an attempt to provide a critical analysis of a variety of data from studies dedicated to ion channel formation and functioning in membranes with different dipole potentials. The types of ion channels found in cellular membranes and pores formed by antimicrobial agents and toxins in artificial lipid membranes are summarized. The mechanisms underlying the influence of the membrane dipole potential on ion channel activity, including dipole-dipole and charge-dipole interactions in the pores and in membranes, are widely discussed. A hypothesis in which lipid rafts in both model and cellular membranes also modulate ion channel activity by virtue of an increased or decreased dipole potential is also considered.
- Добавил в систему: Ефимова Светлана Сергеевна