Comparative analysis of the antineoplastic activity of C60 fullerene with 5-fluorouracil and pyrrole derivative in vivoстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 4 апреля 2017 г.
Аннотация:The antitumor activity of water-soluble C60 fullerene (С60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1Н-pyrrol-2,5-dione (МІ-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1,2-dimethylhydrazine (DMH) in rats. The number, size and location of the tumors were measured and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of С60FAS and МІ-1. Because these drugs have different mechanism of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.