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Comparative analysis of the antineoplastic activity of C60 fullerene with 5-fluorouracil and pyrrole derivative in vivoстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 апреля 2017 г.
- Авторы: Lynchak O.V., Prylutskyy Yu I., Rybalchenko V.K., Kyzyma O.A., Soloviov D., Kostjukov V.V., Evstigneev M.P., Ritter U., Scharff P.
- Журнал: Nanoscale Research Letters
- Том: 12
- Год издания: 2017
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 1
- Последняя страница: 8
- DOI: 10.1186/s11671-016-1775-0
- Аннотация: The antitumor activity of water-soluble C60 fullerene (С60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1Н-pyrrol-2,5-dione (МІ-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1,2-dimethylhydrazine (DMH) in rats. The number, size and location of the tumors were measured and the pathology was examined. It was found that the number of tumors and total lesion area decreased significantly under the action of С60FAS and МІ-1. Because these drugs have different mechanism of action, their simultaneous administration can potentially increase the effectiveness and significantly reduce the side effects of antitumor therapy.
- Добавил в систему: Евстигнеев Максим Павлович