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The effect of NaK2Cl symport and chloride channel permeability on ion flux balance and on transmembrane ion distribution in different types of animal cellsстатья
Статья опубликована в журнале из списка RSCI Web of Science
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 21 августа 2017 г.
- Авторы: Vereninov A.A., Glushankova L.N., Rubashkin A.A.
- Журнал: Цитология
- Том: 39
- Номер: 8
- Год издания: 1997
- Издательство: Наука
- Местоположение издательства: СПб.
- Первая страница: 727
- Последняя страница: 739
- Аннотация: The relationships between monovalent ion fluxes via major cell membrane pathways (Na/K pump, NaK2Cl symporter, electroconductive sodium, potassium and chloride channels) and steady state transmembrane ion distribution, membrane potential and cell water content were calculated for the high potassium animal cells with high and low membrane potential. It is found that variation in NaK2Cl symport or chloride electroconductive permeability causing changes in cell water content of high magnitude do not lead to significant changes in the intracellular Na/K ratio or membrane potential, in contrast to the effects caused by variation in the Na/K pump fluxes or permeability of the Na and K channels. It is shown that water content in cells with a high membrane potential, e.g. of about 70 mV, cannot be increased due to an increase in NaK2Cl symport by more than 1.6 times. In cells with a low membrane potential an increase in symport leads to a decrease in water content, which is also limited. In cells with membrane potential of about 10 mV the water content cannot be decreased more than by 1.8 times. When NaK2Cl symporter is operating, the effect of chloride channel permeability on the ion and water balance is quite opposite to the symport and is limited by the same boundaries. It is shown that effects caused by changes in symport and in chloride permeability can be differentiated only by the analysis of kinetic (fluxes, transport rate constants etc.) but not "static" characteristics of ion distribution. It is shown that under some circumstances the influence of NaK2Cl symport and chloride channel permeability on ion and water balance can be strong even at a very small symport share in the overall flux.
- Добавил в систему: Рубашкин Андрей Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | текст статьи на русском | Tsitologiya_1997_V39_N8.pdf | 830,1 КБ | 17 августа 2017 [RubashkinAA] |