Tunable Self-Assembled Peptide Hydrogel Sensor for Pharma Cold Supply Chain

Авторы: Tikhonova Tatiana N., Cohen-Gerassi Dana, Arnon Zohar A., Efremov Yuri, Timashev Peter, Adler-Abramovich Lihi, Shirshin Evgeny A.
Журнал: ACS applied materials & interfaces
Том: 14
Номер: 50
Год издания: 2022
Издательство: American Chemical Society
Местоположение издательства: United States
Первая страница: 55392
Последняя страница: 55401
DOI: 10.1021/acsami.2c17609
Аннотация: Defrost sensors are a crucial element for proper functioning of the pharmaceutical cold chain. In this paper, the self-assembled peptide-based hydrogels were used to construct a sensitive defrost sensor for the transportation and storage of medications and biomaterials. The turbidity of the peptide hydrogel was employed as a marker of the temperature regime. The gelation kinetics under different conditions was studied to detect various stages of hydrogel structural transitions aimed at tuning the system properties. The developed sensor can be stored at room temperature for a long period, irreversibly indicates whether the product has been thawed, and can be adjusted to a specific temperature range and detection time.
Добавил в систему: Тихонова Татьяна Николаевна

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