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Novel Adsorbents for HILIC Obtained via the Ugi Multicomponent Reaction Varying Isocyanide and Carbonyl Compoundтезисы доклада
- Авторы: Chikurova Natalia, Shemiakina Anna, Belyaeva Alina, Chernobrovkina Alla, Shpigun Oleg
- Сборник: 33rd International Symposium on Chromatography – ISC 2022
- Тезисы
- Год издания: 2022
- Место издания: Hungarian Society for Separation Sciences, HSSS
- Первая страница: с.239
- Номер статьи: P-131
- Аннотация: Selectivity and efficiency in HILIC generally depend on the structure of the stationaryphase, therefore, the actual direction in the method development is the synthesis of noveladsorbents and the study of their properties. Modification of silica substrate is not onlyto increase its hydrophilicity, but also opens up a versatile method to synthesizeadsorbents with enhanced selectivity for diverse analytical tasks.The aim of this work was to use flexibility of combinatorial Ugi reaction with usingdifferent commercially available compounds to manipulate the selectivity and increaseefficiency of the resulting phases. A series of novel stationary phases was obtained byconducting the Ugi reaction directly on 3-aminopropyl silica substrate surface varying thestructure of the carbonyl compound (acetone, 2-acetylfuran, 2-acetylpyrrole, andacetaldehyde) and isocyanide (tert-butyl isocyanide, ethyl isocyanacetate, 2-morpholinoethyl isocyanide, p-toluenesulfonylmethyl isocyanide, and diethylisocyanomethylphosphonate). To increase the yield of the heterogenous reaction asynthesis time, a catalyst, and a solvent nature was varied.Varying components in the Ugi reaction had a significant influence on the selectivity ofthe adsorbents toward sugars, amino acids, nucleobases and nucleosides, organic acids,and water-soluble vitamins. A 15–50% increase in the obtained phases efficiency (up to60000 N/m) for different polar analytes as compared to the substrate confirmed theprospects for the formation of the proposed functional layers.
- Добавил в систему: Чернобровкина Алла Валерьевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | file_Ugi.pdf | file_Ugi.pdf | 1,2 МБ | 29 декабря 2022 [AllaChernobrovkina] |