Contrasting effects of α-tocopheryl succinate on cisplatin- and etoposide-induced apoptosisстатья
Информация о цитировании статьи получена из
Web of Science ,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 декабря 2013 г.
Авторы:
Kruspig B. ,
Zhivotovsky B. ,
Gogvadze V.
Журнал:
Mitochondrion
Том:
13
Номер:
5
Год издания:
2013
Издательство:
Elsevier BV
Местоположение издательства:
Netherlands
Первая страница:
533
Последняя страница:
538
DOI:
10.1016/j.mito.2012.08.001
Аннотация:
Targeting mitochondria is a promising strategy in tumor cell elimination. d-α-tocopheryl succinate (α-TOS), a redox-silent analog of vitamin E, is a potentially powerful tool for fighting tumors by directly affecting mitochondria. However, when used at low concentrations it can suppress apoptosis induced by the conventionally used anticancer drug cisplatin. In cells treated with cisplatin, 30. μM α-TOS prominently attenuated the manifestation of characteristic features of apoptosis - release of cytochrome c from mitochondria, caspase-3-like activity, and cleavage of poly(ADP-ribose) polymerase. In contrast, cell death induced by etoposide was not inhibited but rather stimulated by α-TOS. Thus, co-treatment with α-TOS and conventional antitumor drugs should be carried out with caution. © 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Добавил в систему:
Животовский Борис Давидович