Аннотация:An approach is developed for calculating the two-loop divergences of effective action in the six-dimensional N=(1,1) supersymmetric Yang–Mills model formulated in 6D, N=(1,0) harmonic superspace as a theory of an interacting N=(1,0) gauge multiplet and hypermultiplet. Most attention is focused on studying divergences in the hypermultiplet sector. A procedure for calculating the two-loop divergent contribution of a supergraph of type “$\infty$” into an effective action depending only on the hypermultiplet is developed.