Green electrocatalytic Assembling of Salicylaldehydes, Kojic Acid, and Malonic Acid Derivatives into 2‐amino‐4H‐chromenes as Potent Anti‐inflammatory Agentsстатья
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Аннотация:Green electrocatalytic multicomponent assembly of salicylaldehydes, kojic acid and malonic acid derivatives in n-propanol in the presence of potassium iodide as an electrolyte in an undivided cell results in the formation of 4-(3-hydroxy-6-(hydroxymethyl)-4-oxo-4H-pyran-2-yl) substituted 2-amino-4H-chromenes in 86–98 % yields. This new electrocatalytic multicomponent process is a facile and efficient environmentally benign way to the functionalized 2-amino-4H-chromenes, containing in the fourth position kojic acid fragment, which are perspective compounds for different biomedical applications, among them in the treatment of human inflammatory diseases. Python-automated docking procedure was carried out and the results support anti-inflammatory potential of the synthesized compounds.
