Аннотация:The relevance of the article is caused by the combination of specialization and diversification as asymmetric forms of production organization. At the present stage, Russias active integration into the global economic space increases the importance of the knowledge-intensive sector of the economy. In this regard, the state has chosen, as the main priority of economic policy at the new stage of development, the path of economy modernization and high-tech innovations, the purpose of which is to achieve sustainable country development by diversifying the economy away from the raw material development direction and preparing the transition to a service-technology economy. The research novelty is the search for new approaches to managing the activities of the main subjects of the production sphere, which are industrial enterprises. The diversification of industrial enterprise activities leads to the emergence of a new problem associated with the formation of an organizational and economic mechanism for managing the process of diversification of enterprises at the mesoregion level.