|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometryстатья
- Авторы: Kravets K.Yu, Timakova S.I., Grechnikov A.A., Borodkov A.S., Laptinskaya P.K., Kuzmin V.S., Simanovsky Ya O.
- Журнал: Journal of Analytical Chemistry
- Том: 77
- Номер: 10
- Год издания: 2022
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 1307
- Последняя страница: 1314
- Оригинальные версии: Скрининг лекарственных соединений в крови методом масс-спектрометрии с ионизацией, индуцированной лазерной плазмой при атмосферном давлении
- DOI: 10.1134/s1061934822100082
- Аннотация: We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on examples of five medicinal compounds: Lidocaine, Bendazole, Papaverine, Chloropyramine, and Carbamazepine. Calibration dependences were obtained in the analysis of model solutions and blood samples; sensitivity coefficients were determined. The relative standard deviation of the results is in the range 20–27%. The APLPI technique can detect promptly and reliably the studied medicinal compounds at concentrations 0.5–6 ng/mL in a sample. The sensitivity of APLPI exceeds that of atmospheric pressure electrospray ionization by 4–16 times.
- Добавил в систему: Лаптинская Полина Константиновна