The formation of β-cyclodextrin complexes with levofloxacin and ceftriaxone as an approach to the regulation of drugs' pharmacokinetic

Yakupova, L.R.; Kopnova, T.Y.; Skuredina, A.A.; Le-Deygen, I.M.; Shustrov, P.N.; Novoselov, A.M.; Kudryashova, E.V.

Авторы: Yakupova L.R., Kopnova T.Yu, Skuredina A.A., Le-Deygen I.M., Shustrov P.N., Novoselov A.M., Kudryashova E.V.
Журнал: Colloid Journal
Том: 85
Номер: 1
Год издания: 2023
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 113
Последняя страница: 126
DOI: 10.1134/S1061933X22600488
Аннотация: The study has been devoted to the complexation of hydroxypropyl-β-cyclodextrin (HPCD) withantibacterial drugs, namely, ceftriaxone (CT) and levofloxacin (LV), which are used to treat respiratory dis-eases, including bacterial infections of the respiratory tract. FTIR and NMR spectroscopic investigationshave shown that the LV–HPCD complex is formed mainly due to the inclusion of the aromatic fragment ofLV into the HPCD cavity; while the CT–HPCD complex is realized on the HPCD surface. Being a morehydrophobic molecule, LV forms ten times stronger complexes with HPCD than does CT: KdisLV-GPCD ~ 10–3 M,while KdisCT-HPCD ~10–2 M at pH 7.4. It has been shown that, for singly charged forms of the preparations,the complexes are two times more stable. Fluorescence spectroscopy has been employed to study the thermo-dynamic parameters for the interaction of dosage forms with human serum albumin. Negative values of ΔHand ΔS of the reaction have indicated both hydrogen bonding and van der Waals interactions during the com-plexation of both drugs with human serum albumin. It has been found that the protein is ~4 times more stronglybound to LV at 37°C as compared with CT. The data obtained will make it possible to improve the characteristicsof the studied drugs and bring the methods of treating severe forms of respiratory diseases to a new level.
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The formation of β-cyclodextrin complexes with levofloxacin and ceftriaxone as an approach to the regulation of drugs' pharmacokineticстатья

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