Excessive α-β Oscillations Mark Enlarged Motor Sign Severity and Parkinson's Disease Duration

Belova, E.; Semenova, U.; Gamaleya, A.; Tomskiy, A.; Sedov, A.

Авторы: Belova Elena, Semenova Ulia, Gamaleya Anna, Tomskiy Alexey, Sedov Alexey
Журнал: Movement Disorders
Том: 38
Год издания: 2023
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Первая страница: 1
Последняя страница: 10
DOI: 10.1002/mds.29393
Аннотация: Background: β Oscillations in the subthalamic nucleus (STN) have been proven to contribute to Parkinson's disease (PD), but the exact borders of β subbands vary substantially across the studies, and information regarding heterogeneity of β rhythmic activity is still limited. Recently, α oscillations in the basal ganglia have also become the focus of PD research.Objectives: The aim was to study rhythmic oscillations in the STN in PD patients to identify different subbands with stable oscillatory peaks within a broad α-β range and to establish their associations with motor symptoms.Methods: Local field potentials inside the STN were recorded during deep brain stimulation (DBS) surgeries. After calculating power spectra and extracting an aperiodic component, oscillatory peaks in the 8- to 35-Hz range with amplitude exceeding 90th percentile were clustered into three bands. Peak parameters were estimated for two lower subbands. Clinical features were compared in patients with and without oscillation peaks in the lowest α-β subband.Results: We isolated α-β (8-15 Hz), β (15-25 Hz), and β-γ (25-35 Hz) subbands within the 8- to 35-Hz spectral range using oscillatory parameters and Ward's hierarchical clustering. Additional α-β oscillatory peaks were found in about half of patients with β peaks; they were located more ventrally compared to β. We have found a significant increase in disease duration, bradykinesia, and rigidity scores in the group with additional α-β peaks.Conclusions: Increased α-β oscillations may emerge as additional phenomena complementing β oscillations; they may mark disease progression in PD and affect DBS stimulation setup. © 2023 International Parkinson and Movement Disorder Society.Keywords: Parkinson's disease; basal ganglia; local field potentials; subthalamic nucleus; α-β oscillations.
Добавил в систему: Гамалея Анна Александровна

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Excessive α-β Oscillations Mark Enlarged Motor Sign Severity and Parkinson's Disease Durationстатья

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