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Nanoemulsion for continuous parenteral infusion of taxanesтезисы доклада
- Авторы: Uglanova S.V., Zaitseva E.A., Varfolomeev S.D., Kabanov A.V., Klyachko N.L.
- Сборник: Proceedings of the 3-rd Russian-Hellenic symposium “Biomaterials and bionanomaterials: Recent Problems and Safety Issues”
- Тезисы
- Год издания: 2012
- Место издания: University of Crete, D. Mendeleyev University of Chemical Technology of Russia Москва
- Первая страница: 40
- Последняя страница: 40
- Аннотация: Paclitaxel is one of the best antineoplastic drugs found from nature in the past decades, it has been found effective against many forms of cancer according data of the National Cancer Institute (NCI). Most anticancer drugs have limitations in clinical administration due to their poor solubility, paclitaxel demonstrates extremely poor water solubility (0,05% mass). Docetaxel belongs to the same class – taxanes, they are close in structure and properties. According to standard chemotherapeutic regimens drugs are given by continuous parenteral infusion. A treatment with 3- or 24-hours intravenous infusion is accepted depending on regimen (dose, combination therapy). The drug loaded lipid containing emulsion appeared to be one of the most convenient because of high drug solubilisation capacity taxane, water solubility considerable raise and prolongation of the drug release process. Purposes of the investigations were to provide opportunity of parenteral infusion, multifold dilution, stability in aqueous infusion solution at least for a few hours. In present paper stabilized emulsions of oil-in-water type (o/w) with nano-scale particle sizes were used. Opportunity of the 24 h continuous infusion in aqueous infusion solution, the circulation of the drug concentration in the blood were investigated. According to the required techniques, the drug formulation was diluted in a ratio of 1:10 and 1:20 with saline dextrose infusion solution. It was demonstrated that the system is stable for a day or two. Dialysis modeling drug circulation in blood plasma demonstrates that emulsion is stable for a long time and prevent active compound from fast release.
- Добавил в систему: Зайцева Елена Анатольевна