Antibacterial Composite Material Based on Polyhydroxybutyrate and Zn-Doped Brushite Cement

Fadeeva, I.V.; Deyneko, D.V.; Knotko, A.V.; Olkhov, A.A.; Slukin, P.V.; Davydova, G.A.; Trubitsyna, T.A.; Preobrazhenskiy, I.I.; Gosteva, A.N.; Antoniac, I.V.; Rau, J.V.

Авторы: Fadeeva I.V., Deyneko D.V., Knotko A.V., Olkhov A.A., Slukin P.V., Davydova G.A., Trubitsyna T.A., Preobrazhenskiy I.I., Gosteva A.N., Antoniac I.V., Rau J.V.
Журнал: Polymers
Том: 15
Год издания: 2023
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 2106-1
Последняя страница: 2106-17
Номер статьи: 2106
DOI: 10.3390/polym15092106
Аннотация: A composite material based on electrospinning printed polyhydroxybutyrate fibers impregnated with brushite cement containing Zn substitution was developed for bone implant applications. Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy were applied for materials characterization. Soaking the composite in Ringer’s solution led to the transformation of brushite into apatite phase, accompanied by the morphology changesof the material. The bending strength of the composite material was measured to be 3.1 0.5 MPa. NCTC mouse fibroblast cells were used to demonstrate by means of the MTT test that the developed material was not cytotoxic. The behavior of the human dental pulp stem cells on the surface of the composite material investigated by the direct contact method was similar to the control. It was found that the developed Zn containing composite material possessed antibacterial properties, as testified by microbiology investigations against bacteria strains of Escherichia coli and Staphylococcus aureus. Thus, the developed composite material is promising for the treatment of damaged tissues with bacterial infection complications.
Добавил в систему: Кнотько Александр Валерьевич

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Antibacterial Composite Material Based on Polyhydroxybutyrate and Zn-Doped Brushite Cementстатья

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