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Ion Transporters Involved in Dissipation of Transmembrane Na+ and K+ Gradients in C2C12 Myotubes Triggered by Electrical Pulse Stimulationстатья
- Авторы: Sidorenko Svetlana V., Klimanova Elizaveta A., Maksimov Eugene G., Lopina Olga D., Orlov Sergei N.
- Журнал: Paracelsus Proceedings of Experimental Medicine
- Номер: 2
- Год издания: 2023
- Издательство: CPBPress
- Местоположение издательства: Germany
- Первая страница: 89
- Последняя страница: 100
- DOI: 10.33594/000000629
- Аннотация: Cultured skeletal muscle cells subjected to electrical pulse stimulation(EPS) are widely employed as an in vitro model of exercising skeletal muscle. Numerous studies demonstrated that sustained excitation of skeletal muscle results in the dissipation of the transmembrane gradient of monovalent cations. During exercises the impending loss of excitability has to be counterbalanced by rapid restoration of the Na+i/K+i ratio. To understand mechanisms of the maintenance of muscle contractility, it is necessary to know which transporters are participated in the dissipation of Na+i and K+i gradients and how to activate Na,K-ATPase for its regeneration. This study was aimed at the identification of ion transporters involved in the dissipation of the transmembrane gradients of Na+ and K+ induced by EPS, and Na,K-ATPase isoforms involved in its restoration.
- Добавил в систему: Климанова Елизавета Андреевна