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Redox active ferrocene-modified pyrimidines and adenine as antitumor agents: strusture, separation of enantiomers, and inhibition of DNA synthesis in tumor cellsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 апреля 2017 г.
- Авторы: Snegur L.V., Zykova S.I., Simenel A.A., Nekrasov Yu S., Starikova Z.A., Peregudova S.M., Ilin M.M., Kachala V.V., Sviridova I.K., Sergeeva N.S.
- Журнал: Russian Chemical Bulletin
- Том: 62
- Номер: 9
- Год издания: 2013
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 2056
- Последняя страница: 2064
- Аннотация: The structures, electrochemical properties, enantiomeric separation of ferrocenyl (alkyl)pyrimidines and ferrocenyl(ethyl)adenine and their effects on the DNA synthesis in tumor cells were studied. Enantiomeric mixtures were separated by HPLC on modified cellulose as the chiral selector. The electrochemical properties of compounds were studied by cyclic voltammetry. All compounds have reversible singleelectron redox transition in the region of 0.52—0.60 V, which belongs to ferrocene—ferrocenium with a positive shift compared to ferrocene (0.52 V). The molecular structure of 1N-(ferrocenylbenzyl)-5-iodocytosine was studied by X-ray diffraction. 1N-(Ferrocenylethyl)adenine was studied for ability to inhibit the DNA synthesis in the human ovarian cancer cell culture by the 3H-thymidine test.
- Добавил в систему: Снегур Любовь Владимировна