Pilot ex vivo study on non-thermal ablation of human prostate adenocarcinoma tissue using boiling histotripsy

Rosnitskiy, P.B.; Tsysar, S.A.; Karzova, M.M.; Buravkov, S.V.; Malkov, P.G.; Danilova, N.V.; Ponomarchuk, E.M.; Sapozhnikov, O.A.; Khokhlova, T.D.; Schade, G.R.; Maxwell, A.D.; Wang, Y.N.; Kadrev, A.V.; Chernyaev, A.L.; Okhobotov, D.A.; Kamalov, A.A.; Khokhlova, V.A.

Авторы: Rosnitskiy P.B., Tsysar S.A., Karzova M.M., Buravkov S.V., Malkov P.G., Danilova N.V., Ponomarchuk E.M., Sapozhnikov O.A., Khokhlova T.D., Schade G.R., Maxwell A.D., Wang Y.N., Kadrev A.V., Chernyaev A.L., Okhobotov D.A., Kamalov A.A., Khokhlova V.A.
Журнал: Ultrasonics
Том: 133
Год издания: 2023
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 1
Последняя страница: 8
Номер статьи: 107029
DOI: 10.1016/j.ultras.2023.107029
Аннотация: Focused ultrasound technologies are of growing interest for noninvasive ablation of localized prostate cancer (PCa). Here we present the results of the first case study evaluating the feasibility of non-thermal mechanical ablation of human prostate adenocarcinoma tissue using the boiling histotripsy (BH) method on ex vivo tissue. High intensity focused ultrasound field was generated using a 1.5-MHz custom-made transducer with nominal F#=0.75. A sonication protocol of 734 W acoustic power, 10-ms long BH-pulses, 30 pulses per focal spot, 1% duty cycle, and 1 mm distance between single foci was tested in an ex vivo human prostate tissue sample containing PCa. The protocol used here has been successfully applied in the previous BH studies for mechanical disintegration of ex vivo prostatic human tissue with benign hyperplasia. BH treatment was monitored using B-mode ultrasound. Post-treatment histologic analysis demonstrated BH produced liquefaction of the targeted tissue volume. BH treated benign prostate parenchyma and PCa had similar tissue fractionation into subcellular fragments. The results of the study demonstrated that PCa tumor tissue can be mechanically ablated using the BH method. Further studies will aim on optimizing protocol parameters to accelerate treatment while maintaining complete destruction of the targeted tissue volume into subcellular debris.
Добавил в систему: Хохлова Вера Александровна

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