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COVID-19 and retinal lesionстатья
- Авторы: Mironova E.M., Markov I.A., Balezina O.P.
- Журнал: Modern technologies in ophtalmology
- Номер: 1
- Год издания: 2023
- Первая страница: 325
- Последняя страница: 330
- DOI: 10.25276/2312-4911-2023-1-325-330
- Аннотация: Three years ago, there were reports of a new COVID-19 disease caused by a coronavirus – SARS-CoV-2. The virus infects various organs and tissues, including the eyes. The article presents the results of new studies on the mechanisms of development of ophthalmopathology, in particular, retinal lesions after COVID-19 disease. During the early phase of the pandemic, SARS-CoV-2 was thought to cause ocular surface lesions associated with conjunctivitis and dry eye syndrome. However, it soon became clear that the posterior segment of the eye was also involved in the pathological process. The literature data presented in the article showed that SARS-CoV-2 can infect and replicate in ganglion cells and retinal photoreceptors. Retinal infection with SARS-CoV-2 induces the expression of inflammatory mediators such as interleukin 33 (IL33), the NLRP1 inflammasome, and others. Interleukin 33 is expressed mainly by Muller's glial cells and retinal pigment epithelium. Infection of retinal cells with SARS-CoV-2 manifests itself in an inflammatory response of immune system factors such as IL33 and NLRP1. Literature data indicate that TRPV1 receptor channels may be important sites interacting with SARS-CoV-2. At the same time, it is known that TRPV1 channels are involved in the development of many eye diseases. The data presented in the article indicate the need for further scientific research in order to search for the structures involved in the life cycle of COVID-19 and substances that block the action of these agents in the event of their pathological functioning. This will help prevent damage to the eye, in particular, the retina in case of COVID-19 disease and the development of postcovid syndrome.
- Добавил в систему: Балезина Ольга Петровна