Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy

Kalinin, R.S.; Shipunova, V.O.; Rubtsov, Y.P.; Ukrainskay, V.M.; Schulga, A.; Konovalova, E.V.; Volkov, D.V.; Yaroshevich, I.A.; Moysenovich, A.M.; Belogurov, A.A.; Telegin, G.B.; Chernov, A.S.; Maschan, M.A.; Terekhov, S.S.; Knorre, V.D.; Khurs, E.; Gnuchev, N.V.; Gabibov, A.G.; Deyev, S.M.

Авторы: Kalinin R.S., Shipunova V.O., Rubtsov Y.P., Ukrainskay V.M., Schulga A., Konovalova E.V., Volkov D.V., Yaroshevich I.A., Moysenovich A.M., Belogurov A.A., Telegin G.B., Chernov A.S., Maschan M.A., Terekhov S.S., Knorre V.D., Khurs E., Gnuchev N.V., Gabibov A.G., Deyev S.M.
Журнал: Doklady Biochemistry and Biophysics
Том: 508
Номер: 1
Год издания: 2023
Издательство: M A I K Nauka - Interperiodica
Местоположение издательства: Russian Federation
Первая страница: 17
Последняя страница: 20
DOI: 10.1134/s1607672922700041
Аннотация: The development of CAR-T specific therapy made a revolution in modern oncology. Despite the pronounced therapeutic effects, this novel approach displayed several crucial limitations caused by the complications in pharmacokinetics and pharmacodynamics controls. The presence of the several severe medical complications of CAR-T therapy initiated a set of attempts aimed to regulate their activity in vivo. We propose to apply the barnase-barstar system to control the cytotoxic antitumor activity of CAR-T cells. To menage the regulation targeting effect of the system we propose to use barstar-modified CAR-T cells together with barnase-based molecules. Barnase was fused with designed ankyrin repeat proteins (DARPins) specific to tumor antigens HER2 (human epidermal growth factor receptor 2) The application of the system demonstrates the pronounced regulatory effects of CAR-T targeting.
Добавил в систему: Мойсенович Анастасия Михайловна

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Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancyстатья Исследовательская статья

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