A replication study of genetic variants associated with high-level musical aptitudeстатья
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Дата последнего поиска статьи во внешних источниках: 17 апреля 2024 г.
Аннотация:Background: Existing genetic studies on musical abilities have focused on various molecular approaches,which determined gene regions/variants implicated in (i) music perception and performancebased on genome-wide linkage and association scans, (ii) differential expression patterns as a response to music listening/performance, (iii) music production in songbirds, and (iiii) neuronal plasticityrelation to music training. The aim of the study: The present study sought to examine the main and combined effects of related gene variants in developing musical abilities in individuals from Russia. In addition, we aimed to obtain the mathematical model with the optimal sensitivity to specific itratio to pedict individual liability for high-level musical aptitude. Materials and methods:A genotyping of the SNCA (rs356168, rs3910105), GATA2 (rs9854612), PCDH7 (rs13109270,rs13146789), UNC5C (rs9307160, ASAP1 (rs3057), SBSPON (rs1007750), GRIN2B (rs3764030),and BDNF (rs6265) gene variants was performed via real-time PCR with endpoint fluorescent detectionin high-level musically skilled students (N = 100, 66% of women) in Moscow (Russia) and correspondingcontrol group (N = 200, 67% of women). The main and combined effects of examinedgene variants on developing musical abilities were assessed via logistic regression models followedby a selection of the best predicting model in R v.4.1.2. Results: We obtained a regression model(AUC = 0.735, P = 0.026), which can predict a higher probability to develop musical aptitude linkedto SNCA rs356168 TT-genotype (β=1.98, P=0.011, OR=7.31, 95%CI 1.66-38.4), SNCA rs3910105TC-genotype (β=1.39, P=0.034, OR=4.16, 95%CI 1.2-16.6), GATA2 rs9854612 A-allele (β=0.83,P=0.082, OR=2.30, 95%CI 0.91-6.11). Moreover, a significant effect of ASAP1 rs3057 on manifestationof musical skills was observed under the dominance deviation from additivity model (β=2.13,P=0.032, OR=1.94, 95%CI 1.05-3.56). Conclusion: Revealed findings testify in the involvement ofdopaminergic neurotransmission and reward mechanisms attributed to