Mechanisms of Interaction of Escherichia Coli Biopolymers with 4-Hexylresorcinolстатья
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Дата последнего поиска статьи во внешних источниках: 17 апреля 2024 г.
Аннотация:In this study, molecular modeling is used to study the interaction of the autoregulatory factor ofbacteria, a chemical analog of the inducers of anabiosis of 4-hexylresorcinol (4HR), with the outer and inner membranes, the porin protein, peptidoglycan, DNA, and the DNA stabilizing protein Dps of the Escherichia coli (E. coli) bacterium. The concentration dependence and molecular mechanisms of the interaction of 4HR with cell polymers are studied by molecular dynamics in the all-atom approximation. The spatial and energy characteristics of 4HR complexes with various cellular components are obtained. Using principal component analysis, the characteristics of DNA and the DNA-binding Dps protein are determined under conditions of various 4HR complexes. The obtained results, which are consistent with the experimental data, allow a deeper understanding of the processes that occur during the protection of the bacterial cell at the level of the envelope and the preservation of DNA by nucleoid proteins.