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Involvement of red blood cells in the regulation of leukotriene synthesis in polymorphonuclear leucocytes upon interaction with Salmonella Typhimuriumстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Golenkina E.A., Galkina S.I., Romanova J.M., Lazarenko M.I., Sud’ina G.F.
- Журнал: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- Том: 119
- Номер: 9
- Год издания: 2011
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Первая страница: 635
- Последняя страница: 642
- DOI: 10.1111/j.1600-0463.2011.02786.x
- Аннотация: Leukotriene (LT) B4 is the primary eicosanoid product of polymorphonuclear leucocytes (PMNLs). We studied LT synthesis in PMNLs upon interaction with Salmonella enterica serovar Typhimurium. Human PMNLs exposed to Salmonella produced LTs; mostly LTB4 and ω-hydroxy-LTB4. Opsonization with normal serum increased the capacity of S. Typhimurium to induce LT synthesis in PMNLs. Addition of red blood cells (RBCs) alone did not activate LT synthesis in PMNLs but did further increase the Salmonella-induced release of LTs. Priming of PMNLs with lipopolysaccharide before the addition of bacteria potentiated LT synthesis in these cells. The effect was more pronounced in the presence of RBCs. We found that RBCs diminished the effect of exogenously added NO donors on LT synthesis in PMNLs. We conclude that RBCs mediate the activation of LT synthesis in PMNLs exposed to Salmonella bacteria at least in part by regulating the intercellular exchange and metabolism of NO.
- Добавил в систему: Судьина Галина Федоровна