Аннотация:The article is written about studying of radiation safety of 188Re-labeled microspheres of albumin preparation (hand mode)for treatment of resistant synovitis. The study material was a radiopharmaceutical based on albumin microspheres 5 –10 µm withrhenium-188 for treatment of resistant synovitis. The studying has led to conclusion the number of radiopharmaceutical portionsprepared by one operator should not exceed 70 times a year, which will ensure that the main limits of equivalent doses to handsand skin with a reserve factor of 2 (250 μSv/h) are not exceeded. Protective equipment should be used to reduce doses to hands, asthe most critical to operator’s body part irradiation