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Stereoselective and efficient chemical transformation of aldehydes and two molecules of pyrazolin-5-one into bis(spiropyrazolone)cyclopropanes under a column chromatography-free protocol at room temperatureстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 17 апреля 2024 г.
- Авторы: Elinson Michail N., Ryzhkova Yuliya E., Ryzhkov Fedor V., Kalashnikova Varvara M., Maslov Oleg I.
- Журнал: Monatshefte für Chemie - Chemical Monthly
- Том: 154
- Номер: 6
- Год издания: 2023
- Первая страница: 625
- Последняя страница: 633
- DOI: 10.1007/s00706-023-03072-5
- Аннотация: The new type of chemical one-pot Knoevenagel-Michael reaction with following stereoselective NBS induced cyclization was found: the direct chemical one-pot transformation of aldehydes and two molecules of pyrazolin-5-one into substituted bispyrazolone cyclopropanes in 85–95% yields. This stereoselective one-pot process is very efficient and convenient way to substituted (R*,R*)-bis(spiro-2,4-dihydro-3H-pyrazol-3-one)cyclopropanes – useful compounds for different biomedical applications, using reasonable and non-expansive starting materials. Mild and facile conditions of this chemical cascade one-pot process and simple reasonable non-chromatographic isolation procedure allow excellent substance yields along with superior stereoselectivity.
- Добавил в систему: Kalashnikova Varvara Mikhailovna