DYT1 Dystonia: Neurophysiological aspects

Indiko, D.; Svetlana, U.; Gamaleya, A.; Tomskiy, A.; Sedov, A.

Авторы: Indiko Dzhalagoniya, Svetlana Usova, Gamaleya Anna, Tomskiy Alexey, Sedov Alexey
Сборник: Poster Abstracts of Samuel Belzberg 6th International Dystonia Symposium, June 1-3, 2023, Dublin, Ireland
Тезисы
Год издания: 2023
Первая страница: P181
Последняя страница: P181
Аннотация: Introduction: The aim of this study was a comparative analysis of the neuronal activity ofglobus pallidus in patients with DYT1 dystonia and idiopathic dystonia.The DYT1 mutation leads to dysfunction of the torsin A protein, resulting in increasedactivation of striatum neurons that suppress the globus pallidus. We wonder how DYT1 mutation can affect the electrophysiological properties of neuronal activity in both segmentsof globus pallidus (GPe and GPi).Materials and Methods: The data were obtained during stereotactic implantation ofelectrodes for deep brain stimulation (DBS). During the operations we performed microelectrode recording of the single unit activity in the GPe and the GPi in 5 patients withDYT1 and in 6 patients without DYT1. We performed offline analysis of neuronal activityparameters and visualized neurons localization in Lead-DBS. All neurons were divided into3 neuron activity types (burst, pause and tonic) depending on neuron activity pattern byusing unsupervised clusterization method.Results: In total, the activity of 662 neurons were analyzed. We found a significantlyreduced firing rate, burst index and burst rate in both segments of the globus pallidus inDYT1 patients. Also, we found significantly increased interburst interval, preburst intervaland pause index. Clusterization showed that in the GPe the differences between DYT1 andnon-DYT1 neuron activity parameters were significant only in burst neurons, while in theGPi the same differences were observed in both burst and pause neurons. The visualizationshowed diversity localization of pause neurons in the GPe.Discussion: Obtained results indicate that DYT1 neurons tend to be more ‘pausy’ and less‘bursty’. Also, the similarity of changes in neural activity in GPe and GPi points on a common pathological focus for these structures, which may be located in the striatum. Difference in the location of pause neurons in the GPe may be due to strong striatal influencewhich alters the activity pattern of the neurons.The study was funded by the Russian Science Foundation project 23-25-00406.
Добавил в систему: Гамалея Анна Александровна

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