Decreased neural responses of the subthalamic nucleus during internally guided voluntary movement in patients with Parkinson’s disease

Filyushkina, V.; Belova, E.; Usova, S.; Tomskiy, A.; Sedov, A.

Авторы: Filyushkina Veronika, Belova Elena, Usova Svetlana, Tomskiy Alexey, Sedov Alexey
Журнал: Clinical Neurophysiology
Том: 150
Номер: Abstracts of the 18th European Congress of Clinical Neurophysiology (ECCN), Marseille, France, May 9–12, 2023
Год издания: 2023
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: e145
Последняя страница: e145
DOI: 10.1016/j.clinph.2023.03.219
Аннотация: Objectives:The research goal is to study the neuronal mechanisms of motor control in subthalamic nucleus (STN) at the level of single unit activityand local field potentials in patients with Parkinson’s disease (PD)performing the same externally triggered (ET) and internally guided(IG) movements.Content:We expected to find neurons in the subthalamic nucleus thatrespond to self-initiated movements only. We found and analyzedsingle unit activity of 26 sensitive neurons in subthalamic nucleusof 12 PD patients who underwent surgery for implantation of electrodes for deep brain stimulation (DBS). We also analyzed the localfield potentials (LFP) in six patients who were externalized DBS electrodes during the postoperative period. All patients performed thesame voluntary ET and IG movements. We did not find neurons thatrespond to only one type of movement. But we showed that in mostcases the amplitude of responses to IG movement was decreased.We also found reduced beta desynchronization during IG movements in contrast to ET movements. According to our results we suppose that the external signal is needed to initiate and restart themotor program and thus make movement more effective in parkinsonian patients. At the same time, in the case of self-initiated movements, the motor program is started once and under the impairedfeedback afferentation observed in PD, the neural responses in thebasal ganglia gradually fade. The reported study was funded byRussian Science Foundation (RSF), project number 22-15-00344.Keywords:Subthalamic nucleus; Motor control; Externally triggered movements; Internally guided movements; Single unit activity; Local fieldpotentials; Parkinson’s disease.
Добавил в систему: Гамалея Анна Александровна

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

Decreased neural responses of the subthalamic nucleus during internally guided voluntary movement in patients with Parkinson’s diseaseстатья Тезисы

Прикрепленные файлы