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Xenon effect on electrophysiological markers in oncology patients with postcastration syndrome during early postoperative period: pilot studiesстатья
- Авторы: Kit Oleg I., Rudenko Mikhail Y., Arapova Yulia Yu, Protasova Tatiana P., Shikhlyarova Alla I., Rostorguev Eduard E., Popova Natalia N., Kuznetsova Natalia S., Pozdnyakova Viktoria V.
- Журнал: Cardiometry
- Номер: 11
- Год издания: 2017
- Первая страница: 85
- Последняя страница: 92
- DOI: 10.12710/cardiometry.2017.11.8592
- Аннотация: Breast cancer (BC) takes a leading position among all malignant neoplasms in women. One of the critical aspects of the radical treatment of BC is the development of post-castration syndrome (PCS) in patients of reproductive age, who as a rule reach physiological, social and professional maturity, competence and status in the period up to 45 years of age. Traditionally used hormone replacement therapy, despite its high efficiency, has a number of contraindications and side effects. Therefore, it is urgent to develop and implement in clinical practice the effective methods of rehabilitation of patients with PCS. One of the main areas of research is the study of the prospects for the use of therapeutic xenon-oxygen mixtures in restorative medicine, as it has a pronounced anti-stress, hormone-modulating, antidepressant and sedative effect. Accordingly, the aim of the present paper is to study the effect of xenon on cardiovascular system markers, brain bioelectric activity and psycho-emotional state in oncology patients with hormone-positive breast cancer in the stage of surgical castration. 8 female oncology patients have been examined: the main group consists of women who received inhalations with a xenon-oxygen mixture on the fifth day after the surgery, and the reference group are the patients with the main course of treatment only. The electrocardiogram and electroencephalogram recording and the 8-color Lüscher test have been performed before, after surgery (ovariectomy) and after the completion of therapy. It has been established that the use of xenon-oxygen mixture in the main group of patients allows reducing the manifestation of somatic and psycho-emotional changes peculiar to PCS. After the course completion no stress of regulatory systems has been observed in patients, a tendency to normalization of myocardial metabolism, positive changes in bioelectrical activity and an improvement in the psychoemotional state have been revealed.
- Добавил в систему: Кузнецова Наталья Сергеевна