New Opportunities for Preoperative Diagnosis of Medullary Thyroid Carcinoma

Lukyanov, S.A.; Sergiyko, S.V.; Titov, S.E.; Beltsevich, D.G.; Veryaskina, Y.A.; Vanushko, V.E.; Urusova, L.S.; Mikheenkov, A.A.; Kozorezova, E.S.; Vorobyov, S.L.; Sleptsov, I.V.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.

Авторы: Lukyanov Sergei A., Sergiyko Sergei V., Titov Sergei E., Beltsevich Dmitry G., Veryaskina Yulia A., Vanushko Vladimir E., Urusova Liliya S., Mikheenkov Alexander A., Kozorezova Evgeniya S., Vorobyov Sergey L., Sleptsov Ilya V.
Журнал: BIOMEDICINES
Том: 11
Номер: 5
Год издания: 2023
Первая страница: 1473
Последняя страница: 1473
DOI: 10.3390/biomedicines11051473
Аннотация: The preoperative diagnostics of medullary thyroid carcinoma (MTC), including the measuring of the blood calcitonin level, has a number of limitations. Particular focus has recently been placed on the role of miRNAs in the development of various malignant tumors; a comparative analysis of accuracy of the existing methods for MTC diagnosis with a novel diagnosis method, evaluation of the miRNA-375 expression level, was performed in this study. The expression level of miRNA-375 in cytology samples from 555 patients with the known histological diagnosis, including 41 patients with confirmed postoperative diagnosis of MTC, was assessed. The diagnostic parameters of the basal calcitonin level, calcitonin in wash-out fluid from the FNAB needle, and miRNA-375 were compared. An assessment of the miRNA-375 expression level made it possible to detect all the MTC samples with a 100% accuracy among all the 555 cytology specimens, as well as in non-informative FNAB specimens, and specimens from the ipsilateral thyroid lobe. Parameters such as sensitivity, specificity, PPV, and NPV were 100%. The miRNA-375 level, unlike calcitonin, does not correlate with tumor volume, so it does not have the so-called “gray zone”. An assessment of the miRNA-375 expression allows one to accurately distinguish MTC from other malignant and benign thyroid tumors
Добавил в систему: Урусова Лилия Сергеевна

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

New Opportunities for Preoperative Diagnosis of Medullary Thyroid Carcinomaстатья

Прикрепленные файлы