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Elderly patients have limited access to systemic therapy for metastatic renal cell carcinoma (mRCC) and shorter overall survival in Russia, Belarus and Kazakhstanстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 20 июня 2024 г.
- Авторы: Tsimafeyeu Ilya, Krasny Sergei, Nurgaliyev Nurzhan, Varlamov Ilya, Petkau Vladislav, Safina Sufia, Zukov Ruslan, Mazhbich Mikhail, Statsenko Galina, Novikova Olga, Zaitsev Igor, Kaidarova Dilara, Shatkovskaya Oxana, Moiseyev Pavel, Rolevich Alexander, Evmenenko Alesya, Popova Irina L., Vladimirova Liubov Yu
- Журнал: Journal of Clinical Oncology
- Том: 37
- Номер: 15_suppl
- Год издания: 2019
- Издательство: American Society of Clinical Oncology
- Местоположение издательства: United States
- Первая страница: e23033
- Последняя страница: e23033
- DOI: 10.1200/jco.2019.37.15_suppl.e23033
- Аннотация: Background: Russia, Belarus and Kazakhstan are countries of the Eurasian Economic Union with upper-middle-income economies. Limited sources of the healthcare system could affect the treatment of individual cancer patients. The data on the treatment outcomes of elderly patients with mRCC are limited in these countries. RENSUR3 registry study assessed real-world data on the use of therapies in mRCC and overall survival (OS) in this population. Methods: Patients from Russia, Belarus and Kazakhstan were included in the retrospective multicenter registry study. To be eligible, patients were required to have mRCC diagnosed from January 2015 to January 2016. Anonymized data were collected through an online registry. The outcomes of interest were OS, patient characteristics and treatment patterns. Results: 1,094 adult mRCC patients were identified. Mean age at diagnosis of mRCC was 62.3 (SD, 11.2) years. 447 (41%) patients were 65 years and older. In total, 595 (54.4%) patients received systemic therapy for metastatic disease. 58% of elderly patients were not treated compared to 37% of younger patients. Cytokines were the most commonly used treatment in elderly patients (115 of 189 patients, 61%) while targeted therapy was more widely used in younger patients (223 of 406, 55%). Median OS was 12.7 months (95% CI 11.3-14.1) and 9.3 months (7.7-9.9) for patients aged < 65 and ≥65 years, respectively (P < 0.0001). Conclusions: More than half of elderly patients received no systemic therapy or had only cytokines for mRCC in Russia, Belarus and Kazakhstan which doubtless negatively affected OS in this population. Novel therapies should be considered as life-saving and a priority in elderly patients.
- Добавил в систему: Владимирова Любовь Юрьевна