|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Mitochondria-Targeted Uncouplers Decrease Inflammatory Reactions in Endothelial Cells by Enhancing Methylation of the ICAM1 Gene Promoterстатья
- Авторы: Zinovkin Roman A., Zinovkina Liudmila A., Makievskaya Ciara I., Galkin Ivan I.
- Журнал: Current molecular pharmacology
- Том: 17
- Год издания: 2023
- Издательство: Bentham Science Publishers
- Местоположение издательства: Netherlands
- Номер статьи: e150823219723
- DOI: 10.2174/1874467217666230815142556
- Аннотация: The study aimed to investigate the effects of low concentrations of mitochondrial uncouplers in endothelial cells on the CpG dinucleotide methylation of the ICAM1 gene promoter. The excessive inflammatory response in the endothelium is responsible for the development of many cardiovascular diseases. Mitochondria are important regulators of endothelial cell functions. Mild uncoupling of oxidative phosphorylation and respiration in endothelial mitochondria exerts a long lasting anti-inflammatory effect. However, the detailed mechanism of the anti-inflammatory activity of mitochondrial uncouplers remains unclear. We hypothesized that mild mitochondrial uncoupling leads to epigenetic changes in genomic DNA contributing to the anti-inflammatory response.
- Добавил в систему: Лапашина Анна Сергеевна