Photoinduced Reactions of Styrylpyridine Derivatives for the In Situ Formation of Selective Ligands for Apyrimidinic DNAстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
Аннотация:The photocyclization reaction of sterically demanding styrylpyridinederivatives was investigated and shown to depend on thetype of substituent. With this method, a 2,2-diphenyl-1,3-benzodioxolo-annelated benzo[c]quinolizinium was synthesized,and its association with regular and abasic site-containingDNA (AP-DNA) was investigated by absorption, fluorescence,circular and linear dichroism spectroscopy. Specifically, thisligand binds preferentially to AP-DNA relative to regular duplexDNA, and the AP-DNA/ligand complex is formed in situ uponirradiation of the styrylpyridine substrate in the presence of theDNA.