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The role of halogenative stress in atherogenic modification of low-density lipoproteinsстатья
- Авторы: Panasenko O.M., Torkhovskaya T.I., Gorudko I.V., Sokolov A.V.
- Журнал: Biochemistry (Moscow)
- Том: 85
- Номер: Suppl 1
- Год издания: 2020
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: S34
- Последняя страница: S55
- DOI: 10.1134/S0006297920140035
- Аннотация: This review discusses formation of reactive halogen species (RHS) catalyzed by myeloperoxidase (MPO), anenzyme mostly present in leukocytes. An imbalance between the RHS production and body’s ability to remove or neutralize them leads to the development of halogenative stress. RHS reactions with proteins, lipids, carbohydrates, and antioxidants in the content of lowdensity lipoproteins (LDLs) of the human blood are described. MPO binds sitespecifically tothe LDL surface and modifies LDL properties and structural organization, which leads to the LDL conversion intoproatherogenic forms captured by monocytes/macrophages, which causes accumulation of cholesterol and its esters in thesecells and their transformation into foam cells, the basis of atherosclerotic plaques. The review describes the biomarkers ofMPO enzymatic activity and halogenative stress, as well as the involvement of the latter in the development of atherosclerosis.
- Добавил в систему: Панасенко Олег Михайлович