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The role of mitochondrial dynamics in cell deathстатья
- Авторы: Orlova DD, Tribulovich VG, Garabadzhiu AV, Barlev NA, Martin S.
- Журнал: Tsitologiya, издательство Maik Nauka/Interperiodica Publishing (Russian Federation)
- Том: 57
- Номер: 3
- Год издания: 2015
- Первая страница: 184
- Последняя страница: 191
- Аннотация: Mitochondria are dynamic organelles whose homeostasis is defined by two opposite processes: fission (or fragmentation), or fusion. Fission of mitochondria results in generation of smaller organelles and fusion is when they produce tubular or net-like structures. Although a number of proteins are already known to control the process of fission/fusion additional regulators controlling these processes are being found. The Bcl-2 family members take part in the regulation of apoptosis and according to the current view are involved in the mitochondrial net-like structure maintenance. In this review we will discuss mechanisms of mitochondrial fission/fusion regulation and summarize the available information on the role of Bcl-2 family members in the regulation of mitochondrial fission/fusion dynamics.
- Добавил в систему: Барлев Николай Анатольевич