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Association of the subunits of the calcium-independent receptor of $\upalpha$-latrotoxinстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 июня 2017 г.
- Авторы: Serova Oxana V., Popova Nadezhda V., Petrenko Alexander G., Deyev Igor E.
- Журнал: Biochemical and Biophysical Research Communications
- Том: 402
- Номер: 4
- Год издания: 2010
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 658
- Последняя страница: 662
- DOI: 10.1016/j.bbrc.2010.10.078
- Аннотация: CIRL-1 also called latrophilin 1 or CL belongs to the family of adhesion G protein coupled receptors (GPCRs) As all members of adhesion GPSR family CIRL 1 consists of two heterologous subunits extracellular hydrophilic p120 and heptahelical membrane protein p85 Both CIRL-1 subunits are encoded by one gene but as a result of intracellular proteolysis of precursor mature receptor has two-subunit structure It was also shown that a minor portion of the CIRL-1 receptor complexes dissociates producing the soluble receptor ectodomain and this dissociation is due to the second cleavage at the site between the site of primary proteolysis and the first transmembrane domain Recently model of independent localization p120 and p85 on the cell surface was proposed In this article we evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex (C) 2010 Elsevier Inc All rights reserved
- Добавил в систему: Петренко Александр Георгиевич