OCT Angiography and Color Doppler Imaging in Glaucoma Diagnosticsстатья
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Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.
Аннотация:The purpose of the study was to evaluate the perfusion of optic nerve head (ONH), peripapillary retina and inner macula in
glaucoma, and determine the relation between retinal and ONH microcirculation, retrobulbar blood flow and structural
parameters. The study involved patients suffering from primary open-angle glaucoma (POAG) (65 eyes) and healthy subjects
matched with respect to age (22 eyes). The eyes were examined by means of Angiovue SD-OCT-А (RTVue-XR Avanti) and
color Doppler imaging (CDI). Also, the study included assessment of retinal thickness and vessel density (VD). VD inside
Disc and Peripapillary VD were were evaluated in ONH and in 750 μm wide elliptical annulus extending from the optic disc
boundary, as Whole En Face VD (disc scan). Whole En Face VD (macula scan) was evaluated in macula (area bounded by a
circle with a diameter of 3 mm) comprising fovea and parafovea in superficial and deep plexuses of the inner layers of retina.
The authors used CDI to measure retrobulbar blood flow parameters, including ophthalmic artery (OA) and short posterior
ciliary artery (SPCA). To perform a statistical analysis, SPSS Statistics 21 and R were used. To determine the diagnostic
ability of each diagnostic parameter indicating retinal hemoperfusion, the authors employed the Wilcoxon-Mann-Whitney test
and AUC. Indicator values for OCT-A and CDI appeared to be reduced in glaucomatous eyes against healthy ones. The largest
AUC for differentiating the early glaucoma from the norm was characteristic of such indicators as: Whole En Face Superficial
VD in macula (AUC 0.8 (0.69-0.90), Peripapillary VD (AUC 0.75 (0.63-0.87), end-diastolic flow velocity in OA (AUC 0.74
(0.61-0.86) and temporal SPCA (AUC 0.72 (0.58-0.86). In order to differentiate the early glaucoma from the moderate/severe
stages of the disease, the most useful were Inferotemporal Peripapillary VD (AUC 0.94 (0.86-1.0) and mean flow velocity in
the CRA (AUC 0.81 (0.69-0.92). In normal eyes, end-diastolic flow velocity in SPCA correlated with Inferotemporal RNFL (r
= 0.747, p < 0.001) and the inferior macular thickness (0.634, p < 0.001). In early glaucoma, the inferotemporal RNFL
correlated with Whole En Face Superficial VD in macula (r = 0.590, p < 0.001), Peripapillary VD (r = 0.340, p = 0.034) and
global loss volume of the ganglion cells complex (r = -0.5, p = 0.001). Inverse relation was observed between the blood flow
parameters in retrobulbar veins and the inferotemporal RNFL and macular thickness in the inferior and nasal areas. There was
no significant correlatuon between IOP and OCT-A parameters in glaucoma subjects. The relation between retinal and ONH
microcirculation and retrobulbar blood flow and structural parameters were revealed in normal eyes and early glaucoma. Both
methods are useful for diagnosis and monitoring of early glaucoma.