|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Analysis of the Protein Binding Sites for Thiamin and Its Derivatives to Elucidate the Molecular Mechanisms of the Noncoenzyme Action of Thiamin (Vitamin B1)статья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Bunik V.I., Aleshin V.A.
- Сборник: Studies in Natural Products Chemistry
- Серия: ISSN 1572-5995
- Том: 53
- Глава в коллективной монографии
- Год издания: 2017
- Издательство: Elsevier, Ltd.
- Местоположение издательства: Oxford, England
- Первая страница: 375
- Последняя страница: 429
- DOI: 10.1016/b978-0-444-63930-1.00011-9
- Аннотация: Thiamin (vitamin B1) is a precursor of thiamin diphosphate (ThDP), which is a known coenzyme of central metabolism. However, data on the noncoenzyme action of thiamin and/or its derivatives have been accumulating since the observation of synaptic corelease of thiamin with acetylcholine. In thiamin-synthesizing organisms, the noncoenzyme action involves the ThDP riboswitch. The energy-dependent biosynthesis of thiamin triphosphate and its adenylated derivatives in all clades provides further evidence for the noncoenzyme action of thiamin and/or derivatives. In the mammalian brain, thiamin is linked to protein acetylation. Thiamin and/or its derivatives are allosteric regulators of the malate and glutamate dehydrogenases, aminotransferases and pyridoxal kinase. Noncanonical thiamin-binding proteins of systemic significance include p53, PARP1, signal-related phosphatases, and kinases. Coupled to coenzyme actions of thiamin in central metabolism, the thiamin binding to noncanonical proteins may well provide for systemic regulation by thiamin-dependent signaling cascades, similar to those involving essential metabolites, such as ATP and NAD+. In particular the site-specific competition between thiamin and (di)nucleotides may attenuate purinergic signaling and NAD+-dependent polyADP-ribosylation or deacetylation. Elucidation of protein targets of the noncoenzyme thiamin action is advanced through structure-based identification of thiamin- or derivatives-binding protein patterns, bioinformatics analysis of their distribution among proteins and pathways, and experimental verification of the pattern-based predictions. As a result, noncanonical thiamin-binding proteins emerge as important players in the thiamin bioactivity essential for human health, including pain relief, immunity, neurodegeneration, and cancer.
- Добавил в систему: Буник-Фаренвальд Виктория-Лариса Ивановна