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The two roles of Ca2+ signalingстатья
- Авторы: Panina Y., Chernyshev A.V., Lyubarsky G.Y., Pérez Koldenkova V.
- Журнал: Preprints
- Год издания: 2020
- Первая страница: 1
- Последняя страница: 62
- DOI: 10.13140/RG.2.2.10318.69440
- Аннотация: Genes are the determinants and limiting constraints of all the possible features a livingorganism can display. Genes, however, are largely lineage-specific, and a strict focus onthem can lead to an overlook of functional analogies existing between organisms belongingto non-related lineages. In the present concept work we propose that: 1) Ca2+ signaling is ageneral, cross-kingdom, regulatory pathway encompassing lineage-specific gene-definedmorphogenesis in multicellular organisms, 2) to understand its way of action, Ca2+signaling should be approached from the viewpoint of the functional blocks involved in theexecution of migration, proliferation and other cellular-level processes. Two major roles areattributed to Ca2+ signaling within this framework: the “classical”, stimulus-transducingtriggering role, and a second one, here termed orchestrating, reflecting the responsiveregulation of Ca2+ signaling properties by Ca2+ signaling itself. Approaching Ca2+ signalingfrom this perspective reveals currently hard-to-formalize general structural features ofliving organisms, experimental validation of which would otherwise require an extremellylarge number of “wet” analyses, and to which bioinformatics methods alone can be blind.
- Добавил в систему: Любарский Георгий Юрьевич