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A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neuronsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Soshnikova Nataliya V., Azieva Asya M., Klimenko Nataliya S., Khamidullina Alvina I., Feoktistov Alexey V., Sheynov Andrey A., Brechalov Alexander V., Tatarskiy Victor V., Georgieva Sofia G.
- Журнал: Frontiers in Cell and Developmental Biology
- Том: 11
- Год издания: 2023
- Издательство: Frontiers Media S.A.
- Местоположение издательства: Lausanne, Switzerland
- DOI: 10.3389/fcell.2023.1271598
- Аннотация: The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells. In this study, we describe a novel variant of the PBAF complex from differentiated neuronal cells, called dcPBAF, that differs from the canonical PBAF existing in proliferating neuroblasts. We describe that in differentiated adult neurons, a specific subunit of PBAF, PHF10, is replaced by a PHF10 isoform that lacks N- and C-terminal domains (called PHF10D). In addition, dcPBAF does not contain the canonical BRD7 subunit. dcPBAF binds promoters of the actively transcribed neuron-specific and housekeeping genes in terminally differentiated neurons of adult mice. Furthermore, in differentiated human neuronal cells, PHF10D-containing dcPBAF maintains a high transcriptional level at several neuron-specific genes.
- Добавил в систему: Азиева Ася Магомедовна